ω-Conotoxin-MVIIC
Blocker of P/Q and N-type Ca2+ channels
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產(chǎn)品名稱: ω-Conotoxin-MVIIC
Blocker of P/Q and N-type Ca2+ channels
產(chǎn)品型號(hào): 08CON002-00100
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無(wú)相關(guān)文檔
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ω-Conotoxin-MVIIC
Blocker of P/Q and N-type Ca2+ channels
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ω-Conotoxin-MVIIC
Blocker of P/Q and N-type Ca2+ channels
ω-conotoxin MVIIC (omega conotoxin MVIIC) is a conotoxin that has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q (IC50=35 nM) and N-type calcium channels. It inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats.
