Product Name
CYP1B1, Polyclonal Antibody
Full Product Name
CYP1B1 Polyclonal Antibody
Product Synonym Names
ASGD6; CP1B; CYPIB1; GLC3A; P4501B1
Product Gene Name
anti-CYP1B1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MPWLQYFPNP VRTVFREFEQ LNRNFSNFIL DKFLRHCESL RPGAAPRDMM DAFILSAEKK AAGDSHGGGA RLDLENVPAT ITDIFGASQD TLSTALQWLL LLFTRYPDVQ TRVQAELDQV VGRDRLPCMG DQPNLPYVLA FLYEAMRFSS FVPVTIPHAT TANTSVLGYH IPKDTVVFVN QWSVNHDPLK WPNPENFDPA RFLDKDGLIN KDLTSRVMIF SVGKRRCIGE ELSKMQLFLF ISILAHQCDF RANPN
3D Structure
ModBase 3D Structure for Q16678
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human CYP1B1
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location
Endoplasmic reticulum membrane, Microsome membrane, Mitochondrion, Peripheral membrane protein
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-CYP1B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CYP1B1 antibody
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
Product Categories/Family for anti-CYP1B1 antibody
Polyclonal Antibodies
Applications Tested/Suitable for anti-CYP1B1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CYP1B1 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
NCBI/Uniprot data below describe general gene information for CYP1B1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000095.2
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NCBI GenBank Nucleotide #
NM_000104.3
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UniProt Primary Accession #
Q16678
[Other Products]
UniProt Secondary Accession #
Q5TZW8; Q93089; Q9H316[Other Products]
UniProt Related Accession #
Q16678[Other Products]
NCBI Official Full Name
cytochrome P450 1B1
NCBI Official Synonym Full Names
cytochrome P450 family 1 subfamily B member 1
NCBI Official Symbol
CYP1B1??[Similar Products]
NCBI Official Synonym Symbols
CP1B; ASGD6; GLC3A; CYPIB1; P4501B1
??[Similar Products]
NCBI Protein Information
cytochrome P450 1B1
UniProt Protein Name
Cytochrome P450 1B1
UniProt Synonym Protein Names
CYPIB1
Protein Family
Cytochrome
UniProt Gene Name
CYP1B1??[Similar Products]
NCBI Summary for CYP1B1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP1B1
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
Research Articles on CYP1B1
1. We present an uncommon mutation and clinical description of CYP1B1 gene analysis demonstrated homozygosity for a 1-bp deletion in exon 2 (c.830delT).
Precautions
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Disclaimer
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