Full Product Name
WRN Antibody
Product Gene Name
anti-WRN antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14191
Other Notes
Small volumes of anti-WRN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-WRN antibody
Western blot analysis WRN using RAW264.7 whole cell lysates
NCBI/Uniprot data below describe general gene information for WRN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000544.2
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NCBI GenBank Nucleotide #
NM_000553.5
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UniProt Primary Accession #
Q14191
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UniProt Secondary Accession #
A1KYY9[Other Products]
UniProt Related Accession #
Q14191[Other Products]
Molecular Weight
162,461 Da
NCBI Official Full Name
Werner syndrome ATP-dependent helicase
NCBI Official Synonym Full Names
Werner syndrome RecQ like helicase
NCBI Official Symbol
WRN??[Similar Products]
NCBI Official Synonym Symbols
RECQ3; RECQL2; RECQL3
??[Similar Products]
NCBI Protein Information
Werner syndrome ATP-dependent helicase
UniProt Protein Name
Werner syndrome ATP-dependent helicase
UniProt Synonym Protein Names
DNA helicase, RecQ-like type 3; RecQ3; Exonuclease WRN (EC:3.1.-.-); RecQ protein-like 2
Protein Family
Werner syndrome ATP-dependent helicase
UniProt Gene Name
WRN??[Similar Products]
UniProt Synonym Gene Names
RECQ3; RECQL2; RecQ3??[Similar Products]
NCBI Summary for WRN
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
UniProt Comments for WRN
Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating s for RP-A (). Plays a role in double-strand break repair after gamma-irradiation.
Research Articles on WRN
1. Data show that helicases RHAU, BLM, and WRN exhibit distinct G-quadruplex (GQ) conformation specificity, but use a common mechanism of repetitive unfolding that leads to disrupting GQ structure multiple times in succession.
Precautions
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