Product Name
Ferritin heavy chain (Fth1), Recombinant Protein
Full Product Name
Recombinant Rat Ferritin heavy chain (Fth1)
Product Gene Name
Fth1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-182aa, full length protein
Sequence
MTTASPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSC YFDRDDVALK NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD RDDWESGLNA MRCALHLEKS VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKSIKELG DHVTNLRKMG APESGMAEYL FDKHTLGHGD ES
3D Structure
ModBase 3D Structure for P19132
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Fth1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Fth1 recombinant protein
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their
biological validity has not been determined.
NCBI/Uniprot data below describe general gene information for Fth1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036980.1
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NCBI GenBank Nucleotide #
NM_012848.2
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UniProt Primary Accession #
P19132
[Other Products]
UniProt Related Accession #
P19132[Other Products]
Molecular Weight
21,127 Da
NCBI Official Full Name
ferritin heavy chain
NCBI Official Synonym Full Names
ferritin heavy chain 1
NCBI Official Symbol
Fth1??[Similar Products]
NCBI Official Synonym Symbols
Fth
??[Similar Products]
NCBI Protein Information
ferritin heavy chain
UniProt Protein Name
Ferritin heavy chain
Protein Family
Iron transporter
UniProt Gene Name
Fth1??[Similar Products]
UniProt Synonym Gene Names
Fth; Ferritin H subunit??[Similar Products]
NCBI Summary for Fth1
overexpressed during hepatic tumor development; used as an early marker for hepatocellular carcinoma [RGD, Feb 2006]
UniProt Comments for Fth1
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney ().
Research Articles on Fth1
1. This work demonstrates the key role of the cytokine IL-1beta in the regulation of a novel intracellular mediator [i.e., the protein ferritin heavy chain (FHC)] of HIV-induced dendritic damage and the resulting neurocognitive impairment.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
