Product Name
TUBB2B, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone AT5B3] (Ig2a,k) to Human TUBB2B
Product Synonym Names
Anti-TUBB2B Antibody (clone AT5B3) IHC-plus; TUBB2B; BA506K6.1; Class IIb beta-tubulin; PMGYSA; RP11-506K6.1; Tubulin; beta 2B; Class II beta-tubulin isotype; Tubulin beta-2B chain; Tubulin; beta 2B class IIb; Human TUBB2B
Product Gene Name
anti-TUBB2B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BVA1
Purity/Purification
Protein G Purified
Form/Format
Phosphate buffered saline, pH 7.4, 0.1% sodium azide
Concentration
1 mg/ml (lot specific)
Immunogen Description
Recombinant human TUBB2b (aa1-445) purified from E Coli
Immunogen Type
Recombinant protein
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-TUBB2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TUBB2B antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-TUBB2B antibody
IHC-P (5 ug/ml)
Immunohistochemistry (IHC) of anti-TUBB2B antibody
Anti-TUBB2B antibody IHC of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunohistochemistry (IHC) of anti-TUBB2B antibody
Anti-TUBB2B antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
NCBI/Uniprot data below describe general gene information for TUBB2B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_821080.1
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NCBI GenBank Nucleotide #
NM_178012.4
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UniProt Primary Accession #
Q9BVA1
[Other Products]
UniProt Secondary Accession #
A8K068[Other Products]
UniProt Related Accession #
Q9BVA1[Other Products]
Molecular Weight
49,953 Da
NCBI Official Full Name
tubulin beta-2B chain
NCBI Official Synonym Full Names
tubulin, beta 2B class IIb
NCBI Official Symbol
TUBB2B??[Similar Products]
NCBI Official Synonym Symbols
PMGYSA; bA506K6.1
??[Similar Products]
NCBI Protein Information
tubulin beta-2B chain; class IIb beta-tubulin; class II beta-tubulin isotype; tubulin, beta polypeptide paralog
UniProt Protein Name
Tubulin beta-2B chain
UniProt Gene Name
TUBB2B??[Similar Products]
UniProt Entry Name
TBB2B_HUMAN
NCBI Summary for TUBB2B
The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
UniProt Comments for TUBB2B
TUBB2B: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB2B is implicated in neuronal migration. Defects in TUBB2B are a cause of polymicrogyria asymmetric (PMGA). PMGA is a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination. Belongs to the tubulin family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 6p25
Cellular Component: microtubule; cytoplasm; nucleus
Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton
Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; neuron migration; transmembrane transport; microtubule-based process
Disease: Polymicrogyria, Symmetric Or Asymmetric
Research Articles on TUBB2B
1. The present study confirms that mutations in tubulin genes are responsible for complex brain malformation.
Precautions
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Disclaimer
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