Mouse anti Dengue virus serotype 4 NS1 antibody – clone CM436

Mouse anti Dengue virus serotype 4 NS1 monoclonal antibody is specific for the NS1 protein of Dengue virus serotype 4. It does not cross-react with Dengue NS1 from other serotypes, nor with NS1 from Zika virus or other flaviviruses. No cross-reactivity is seen with Chikungunya virus proteins (E1, E2 and C).

This mouse anti Dengue virus serotype 4 NS1 antibody is suitable for use in direct ELISA and in sandwich ELISA.

The NS1 protein is a major non-structural protein expressed by the Dengue Virus. The NS1 monomer is a glycosylated protein of approximately 45kD, which associates with lipids and forms a homodimer inside infected cells. It is necessary for viral replication, and is also secreted into the extracellular space as a hexameric lipoprotein particle, which is involved in immune evasion and pathogenesis by interacting with components from both the innate and adaptive immune systems, as well as other host factors. NS1 is one of the major antigenic markers for viral infection with Dengue.

With more than one-third of the world’s population living in areas at risk of transmission, dengue infection is a leading cause of illness and death in the tropics and subtropics (ref WHO for Guidelines for Diagnosis, Treatment, Prevention & Control, 2009) As many as 100 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are no vaccines available to prevent infection with dengue virus.

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